Hyman, Bradley T

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Genetic influences on memory performance in familial Alzheimer disease.

J H Lee; A Flaquer; Y Stern; B Tycko; R Mayeux (Profiled Authors: Mayeux, Richard; Stern, Yaakov)

Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Neurology 2004;62(3):414-21.

OBJECTIVE: To investigate the heritability of memory and other cognitive measures in families with multiple individuals with Alzheimer disease (AD) to determine if neuropsychological measures can be used to better understand genetic contributions to AD. METHODS: The genetic contributions to the variation in declarative memory, attention, abstract reasoning, language, and visuospatial function using a variance component method were estimated. For memory scores, the proportion of genetic contribution was estimated, controlling for APOE. RESULTS: The unadjusted heritability estimates for the declarative memory tasks ranged from 0.47 for delayed recall to 0.25 for delayed recognition, where a heritability estimate of 1 indicates that genetic factors explain all of the phenotypic variance and a heritability score of 0 indicates that genetic factors explain none. When adjusted for sex, age, education, and general intelligence, the heritability estimates increased to 0.60 for delayed recall and 0.41 for delayed recognition. None of the other cognitive tests showed heritability estimates as high as that observed for memory. When the influence of APOE was taken into account, the heritability estimates changed modestly for delayed recall and consistent long-term retrieval, whereas the estimates for other memory scores did not change, suggesting that APOE contributes little to these memory scores. CONCLUSIONS: Declarative memory in familial AD is under strong genetic influence, only part of which is attributable to APOE. Memory performance should prove to be a useful phenotypic component in the investigation of the genetic basis of AD.

3 Originating Grant

• 1.

  MAYEUX, RICHARD

  Genetic Epidemiology of Alzheimer's Disease in Hispanics

  1 December 1998 - 31 January 2014

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 10,703,458

• 2.

  Mayeux, Richard P

  GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICS

  1 December 1998 - 31 January 2004

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 5,549,515

• 3.

  Mayeux, Richard

  Epidemiology of Dementia In An Urban Community

  1 February 1989 - 30 June 2009

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 40,531,208

Scientific Context

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