Cotman, Carl W

Publication Detail

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Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs.

Norton W Milgram; Elizabeth Head; Steven C Zicker; Candace Ikeda-Douglas; Heather Murphey; Bruce A Muggenberg; Christina T Siwak; P Dwight Tapp; Stephen R Lowry; Carl W Cotman (Profiled Author: Cotman, Carl W)

Division of Life Sciences, University of Toronto, 1265 Military Trail, Scarborough, Ont., Canada M1C 1A4. milgram@psych.utoronto.ca
Experimental gerontology 2004;39(5):753-65.

The effects of long-term treatment with both antioxidants and a program of behavioral enrichment were studied as part of a longitudinal investigation of cognitive aging in beagle dogs. Baseline performance on a battery of cognitive tests was used to assign 48 aged dogs (9-12 years) into four cognitively equivalent groups, of 12 animals per group: Group CC (control food-control environment), group CE (control food-enriched environment); Group AC (antioxidant fortified food-control environment); Group AE (fortified food-enriched environment). We also tested a group of young dogs fed the control food and a second group fed the fortified food. Both groups of young dogs received a program of behavioral enrichment. To evaluate the effects of the interventions on cognition after 1 year, the dogs were tested on a size discrimination learning task and subsequently on a size discrimination reversal learning task. Both tasks showed age-sensitivity, with old dogs performing more poorly than young dogs. Both tasks were also improved by both the fortified food and the behavioral enrichment. However, in both instances the treatment effects largely reflected improved performance in the combined treatment group. These results suggest that the effectiveness of antioxidants in attenuating age-dependent cognitive decline is dependent on behavioral and environmental experience.

2 Originating Grant

• 1.

  COTMAN, CARL WAYNE

  The Canine as an Animal Model of Human Aging

  30 September 1995 - 31 August 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 3,935,610

• 2.

  Cotman, Carl W

  CANINE AS AN ANIMAL MODEL OF HUMAN AGING

  30 September 1995 - 31 August 2006

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 3,710,320

Scientific Context

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