Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Alpha 1-antitrypsin and alpha 1-antichymotrypsin are in the lesions of Alzheimer's disease.

P A Gollin; R N Kalaria; P Eikelenboom; A Rozemuller; G Perry (Profiled Author: Perry, George)

Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106-4901.
Neuroreport 1992;3(2):201-3.

We performed immunocytochemistry to localize alpha 1-antichymotrypsin and alpha 1-antitrypsin in tissue sections of Alzheimer disease patients. Our results show that both serine protease inhibitors are localized in neurofibrillary tangles and senile plaques. Using various monoclonal and polyclonal antibodies, immunolabeling was evident in formalin, methacarn or acetone-fixed sections. Brief pretreatments of sections with either formic acid or guanidine-HCl were also necessary to reveal clear immunostaining of the lesions with two of the antibodies. We suggest that both alpha 1-antitrypsin and alpha 1-antichymotrypsin may be functionally involved in the pathogenesis of the lesions of Alzheimer's disease. Like alpha 1-antichymotrypsin, the major cell producing alpha 1-antitrypsin is likely to be astrocytes since the protein was localized there and astrocytes are involved in both lesions.

3 Originating Grant

• 1.

  PERRY, GEORGE

  NEUROFIBRILLARY PATHOLOGY IN ALZHEIMER DISEASE

  1 September 1990 - 30 November 2000

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 1,191,333

• 2.

  PERRY, GEORGE

  AMYLOID PRECURSOR IN ALZHEIMER DISEASE

  1 September 1988 - 31 August 1993

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 299,729

• 3.

  PERRY, GEORGE

  AMYLOID PRECURSOR IN ALZHEIMERS DISEASE

  1 April 1988 - 30 June 1995

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 536,600

Scientific Context

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