Markesbery, William R

Publication Detail

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Metal ions and oxidative protein modification in neurological disease.

Lawrence M Sayre; Paula I Moreira; Mark A Smith; George Perry (Profiled Authors: Smith, Mark A; Perry, George)

Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. lms3@po.cwru.edu
Annali dell'Istituto superiore di sanità 2005;41(2):143-64.

This review highlights the role of oxidative stress and imbalances in metal ion homeostasis in the neurodegenerative diseases Alzheimer's disease and Parkinson's disease and in the progressive demyelinating disease multiple sclerosis. The chemistry and biochemistry of oxidative stress-induced protein damage are first described, followed by the evidence for a pathological role of oxidative stress in these disease states. It is tempting to speculate that free radical oxygen chemistry contributes to pathogenesis in all these conditions, though it is as yet undetermined what types of oxidative changes occur early in the disease, and what types are secondary manifestations of neuronal degeneration.

1 Originating Grant

• 1.

  Smith, Mark A

  METABOLIC ABNORMALITIES IN ALZHEIMER DISEASE

  1 May 1999 - 30 April 2006

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 750,386

Scientific Context

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