Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies.

M Haltia; J Ghiso; T Wisniewski; S Kiuru; D Miller; B Frangione (Profiled Author: Frangione, Blas)

Department of Pathology, New York University Medical Center, NY 10016.
Neurobiology of aging 1991;12(4):313-6.

Familial amyloidosis, Finnish type (FAF), is an autosomal dominant form of amyloidosis which is related to a point mutation in the gelsolin gene localized on chromosome 9. The mutation corresponds to codon 187 of the secreted form of gelsolin, and is expressed in the amyloid fibril at residue 15. Our original FAF patient was demented, and neuropathological analysis showed Alzheimer type brain lesions associated with both classical and cortical Lewy bodies. Furthermore, antiserum against the gelsolin-derived FAF amyloid reacted strongly with both classical and cortical Lewy bodies of this FAF patient. In preliminary experiments similar results were obtained in cases of Parkinson's disease and diffuse Lewy body disease. These observations may indicate a role for gelsolin in the pathogenesis of Parkinson's disease and related conditions.

5 Originating Grant

• 1.

  Frangione, Blas

  AMYLOID ANGIOPATHY, EARLY PLAQUES & AGING

  1 January 1990 - 31 August 2006

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,063,685

• 2.

  Frangione, Blas

  Amyloidosis and Alzheimer's Disease

  1 July 1985 - 30 June 2007

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,467,436

• 3.

  FRANGIONE, BLAS

  AMYLOIDOSIS AND ALZHEIMERS DISEASE

  1 July 1985 - 30 June 1997

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 3,049,140

• 4.

  Frangione, Blas

  CONFORMATIONAL DISORDERS--AMYLOID AND PRION PROTEINS

  1 September 1978 - 31 March 2006

  NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

  Total Funding: $ 3,600,812

• 5.

  FRANGIONE, BLAS

  STRUCTURE OF IMMUNOGLOBULINS AND RELATED PROTEINS

  1 September 1978 - 31 March 1999

  NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

  Total Funding: $ 2,819,853

Scientific Context

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