Pericak-Vance, Margaret A.

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Lack of association between autism and SLC25A12.

Raquel Rabionet; Jacob L McCauley; James M Jaworski; Allison E Ashley-Koch; Eden R Martin; James S Sutcliffe; Jonathan L Haines; G Robert DeLong; Ruth K Abramson; Harry H Wright; et al. (Profiled Authors: Haines, Jonathan L; Pericak-Vance, Margaret A.; Gilbert, John R)

Center for Human Genetics, Department of Medicine, Duke University Medical Center, 595 LaSalle St., Durham, NC 27710, USA.
The American journal of psychiatry 2006;163(5):929-31.

OBJECTIVE: Autism has a strong, complex genetic component, most likely involving several genes. Multiple genomic screens have shown evidence suggesting linkage to chromosome 2q31-q33, which includes the SLC25A12 gene. Recently, an association between autism risk and two single nucleotide polymorphisms (SNPs) in SLC25A12 was reported. This study aimed to test for association in SLC25A12 in an independent data set of 327 families with autistic offspring. METHOD: The authors analyzed two SNPs that were significant in the previous study group, as well as seven additional SNPs within the gene. Association analyses for individual SNPs as well as haplotypes were performed. RESULTS: There was no evidence of an association between SLC25A12 and autism. CONCLUSIONS: These results suggest that SLC25A12 is not a major contributor to autism risk in these families.

2 Originating Grant

• 1.

  Pericak-Vance, Margaret A

  Molecular and Genetic Epidemiology of Autism

  1 July 1997 - 30 April 2007

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 4,107,387

• 2.

  Pericakvance, Margaret A

  Genetic Studies in Neurological Disorders

  1 March 1997 - 31 March 2009

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 18,660,474

Scientific Context

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