Price, Donald L

Publication Detail

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Aged non-human primates: an animal model of age-associated neurodegenerative disease.

D L Price; L J Martin; S S Sisodia; M V Wagster; E H Koo; L C Walker; V E Koliatsos; L C Cork (Profiled Authors: Price, Donald L; Koo, Edward H; Sisodia, Sangram S)

Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205-2181.
Brain pathology (Zurich, Switzerland) 1991;1(4):287-96.

Aged non-human primates develop age-associated behavioral and brain abnormalities similar to those that occur in aged humans and, to a greater extent, in individuals with Alzheimer's disease. Declines in performance on cognitive and memory tasks begin at the monkey equivalent of late-middle life. As occurs in elderly humans, significant differences have been demonstrated in levels of performance between animals within older age groups. The brains of old monkeys show degenerative changes in neurons, abnormal axons and neurites (particularly in telencephalic areas), and deposits of amyloid in senile plaques and around blood vessels. Moreover, in some older animals, decrements occur in markers of specific neurotransmitter circuits, including the basal forebrain cholinergic system. It has been suggested that alterations in these cholinergic neurons contribute to the memory deficits that occur in older individuals. Because axotomy-induced retrograde degeneration of these neurons can be prevented by the administration of nerve growth factor, we have begun studies to determine whether administration of nerve growth factor improves performance of aged animals on memory tasks. This review describes the complementary nature of studies of non-human primates and human subjects, illustrating how these investigations can clarify factors that influence behavior and brain biology in age-associated diseases.

5 Originating Grant

• 1.

  Price, Donald L

  Alzheimer's Disease and Animal Models

  15 July 1997 - 31 March 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 44,095,695

• 2.

  ALBERT, MARILYN B

  Johns Hopkins Alzheimer's Disease Research Center

  15 July 1997 - 31 March 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 5,559,946

• 3.

  PRICE, DONALD L

  THE FOREBRAIN CHOLINERGIC SYSTEM IN HEALTH AND DISEASE

  1 April 1984 - 30 June 1992

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 4,029,351

• 4.

  PRICE, DONALD L

  DISORDERS OF AGING--TRANSMITTER SYSTEMS & NEUROTROPHINS

  1 April 1984 - 30 June 1997

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 10,370,755

• 5.

  PRICE, DONALD L

  TRAINING PROGRAM IN EXPERIMENTAL NEUROPATHOLOGY

  1 July 1980 - 30 June 1996

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 252,576

Scientific Context

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