The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology.
Roberts aboratory for NeurodegenerativeDisease Research, Sun Health Research Institute, Sun City, AZ, USA.
The journal of nutrition, health & aging 2006;10(4):247-54.
Mounting evidence suggests copper may influence the progression of Alzheimer's disease by reducing clearance of the amyloid beta protein (Abeta) from the brain. Previous experiments show that addition of only 0.12 PPM copper (one-tenth the Environmental Protection Agency Human consumption limits) to distilled water was sufficient to precipitate the accumulation of Abeta in the brains of cholesterol-fed rabbits (1). Here we report that addition of copper to the drinking water of spontaneously hypercholesterolemic Watanabe rabbits, cholesterol-fed beagles and rabbits, PS1/APP transgenic mice produced significantly enhanced brain levels of Abeta. In contrast to the effects of copper, we found that aluminum- or zinc-ion-supplemented distilled water did not have a significant effect on brain Ab accumulation in cholesterol-fed rabbits. We also report that administration of distilled water produced a reduction in the expected accumulation of Ab in three separate animal models. Collectively, these data suggest that water quality may have a significant influence on disease progression and Ab neuropathology in AD.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
MARKESBERY, WILLIAM R
1 April 1981 - 31 March 1985
NATIONAL INSTITUTE ON AGING
Total Funding: $ 243,656
RAPOPORT, STANLEY I
NATIONAL INSTITUTE ON AGING
Total Funding: $ 0
GANDY, SAMUEL E
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NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE
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