Cat and mouse.

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Greg M Cole; Sally A Frautschy (Profiled Author: Cole, Greg M)

Greater Los Angeles Healthcare System, Veterans Administration Medical Center, Geriatric Research Education Clinical Center, North Hills, California 91343, USA.
Neuron 2006;51(6):671-2.

PubMed

Abstract

The role of cathepsin B, a lysosomal protease implicated in amyloid-beta (Abeta1-42) metabolism, in Alzheimer's disease remains controversial. In this issue of Neuron, Mueller-Steiner et al. manipulate the expression of cathepsin B in aged APP transgenic mice, observing that increased expression degrades preformed oligomeric and fibrillar amyloid, while inactivation accelerates beta-amyloidosis.

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.

Related Grants

1.

IQBAL, KHALID

I2PP2A: A Therapeutic Target

2 September 2011 - 30 June 2014
FOGARTY INTERNATIONAL CENTER
Total Funding: $ 70,352
2.

MUFSON, ELLIOTT JAY

Galanin in Alzheimer's Disease

29 September 1991 - 31 May 2012
NATIONAL INSTITUTE ON AGING
Total Funding: $ 5,750,823
3.

TANZI, RUDOLPH EMILE

Characterization of Alzheimer's Mutations in ADAM10.

30 September 2012 - 31 August 2017
NATIONAL INSTITUTE ON AGING
Total Funding: $ 345,936

Related Publications

1.
2001

P Das; M P Murphy; L H Younkin; S G Younkin; T E Golde

Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
Neurobiology of aging 2001;22(5):721-7.
2.
2003

Robert A Marr; Edward Rockenstein; Atish Mukherjee; Mark S Kindy; Louis B Hersh; Fred H Gage; Inder M Verma; Eliezer Masliah

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):1992-6.
3.
2008

Vincent Laporte; Ghania Ait-Ghezala; Claude-Henry Volmar; Christopher Ganey; Nowell Ganey; Marcie Wood; Michael Mullan

CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Brain research 2008;1231():132-42.