Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Inflammatory changes parallel the early stages of Alzheimer disease.

A Parachikova; M G Agadjanyan; D H Cribbs; M Blurton-Jones; V Perreau; J Rogers; T G Beach; C W Cotman (Profiled Author: Cotman, Carl W)

Institute for Brain Aging & Dementia, University of California, 1113 Gillespie Neuroscience Research Facility, Irvine, CA 92697-4540, USA. aparachi@uci.edu
Neurobiology of aging 2007;28(12):1821-33.

Alzheimer disease (AD) is the most prominent cause of dementia in the elderly. To determine changes in the AD brain that may mediate the transition into dementia, the gene expression of approximately 10,000 full-length genes was compared in mild/moderate dementia cases to non-demented controls that exhibited high AD pathology. Including this latter group distinguishes this work from previous studies in that it allows analysis of early cognitive loss. Compared to non-demented high-pathology controls, the hippocampus of AD cases with mild/moderate dementia had increased gene expression of the inflammatory molecule major histocompatibility complex (MHC) II, as assessed with microarray analysis. MHC II protein levels were also increased and inversely correlated with cognitive ability. Interestingly, the mild/moderate AD dementia cases also exhibited decreased number of T cells in the hippocampus and the cortex compared to controls. In conclusion, transition into AD dementia correlates with increased MHC II(+) microglia-mediated immunity and is paradoxically paralleled by a decrease in T cell number, suggesting immune dysfunction.

3 Originating Grant

• 1.

  Cotman, Carl W

  Brain Aging & Gene Expression Patterns Using Microarrays

  30 September 2003 - 31 July 2008

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 2,450,598

• 2.

  COTMAN, CARL WAYNE

  ADRC of the University of California, Irvine

  15 April 2000 - 31 March 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 19,671,992

• 3.

  COTMAN, CARL WAYNE

  Behavior and Neural Plasticity in the Aged

  1 August 1997 - 31 March 2013

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 30,822,252

Scientific Context

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