Younkin, Steven G

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Relation of plasma homocysteine to plasma amyloid beta levels.

José A Luchsinger; Ming-Xin Tang; Joshua Miller; Ralph Green; Pankash D Mehta; Richard Mayeux (Profiled Author: Mayeux, Richard)

Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Neurochemical research 2007;32(4-5):775-81.

BACKGROUND: Elevated plasma homocysteine and amyloid beta (Abeta) have been associated with Alzheimer's disease (AD). We investigated the cross-sectional association between these biomarkers. METHODS: We used linear regression to relate plasma homocysteine and Abeta adjusting for age, gender, creatinine, APOE-epsilon4, and ethnic group in 327 persons aged 78 +/- 6.6 years. RESULTS: Plasma homocysteine correlated with age, serum creatinine, plasma Abeta40 and Abeta42, and was inversely correlated with serum vitamin B12, and folate. Abeta42, but not Abeta40, was related to later development of dementia. Homocysteine was related to higher Abeta40 levels (coefficient = 2.0; P < 0.0001) and this association was attenuated after adjustment for creatinine (coefficient = 1.0; P < 0.0001). The crude association between homocysteine and Abeta42 was weaker (coefficient = 0.5; P = 0.01) and became non-significant after adjustment for creatinine (coefficient = 0.4; P = 0.06). These associations were unrelated to ethnicity, the presence of APOE-epsilon4 or dementia. Analyses by quartiles of homocysteine showed that these association were driven primarily by the fourth quartile. CONCLUSIONS: Plasma homocysteine is directly related to Abeta40. The association with Abeta42 is not significant. These results seem to indicate that homocysteine is related to aging but not specifically to AD.

1 Originating Grant

• 1.

  Mayeux, Richard

  Epidemiology of Dementia In An Urban Community

  1 February 1989 - 30 June 2009

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 40,531,208

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.