Mufson, Elliott J

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Women's cognitive and affective health and neuropsychiatry.

Amy Aloysi; Kathleen Van Dyk; Mary Sano (Profiled Author: Sano, Mary)

The Alzheimer Disease Research Center, Mount Sinai School of Medicine, New York, NY, USA.
The Mount Sinai journal of medicine, New York 2006;73(7):967-75.

Recent interest in women's health has focused on the cognitive consequences of aging and hormonal changes. Based on hypotheses about estrogenic effects in the central nervous system (CNS), large-scale clinical trials were designed to address the efficacy of hormone replacement on protection against dementia and cognitive decline. Surprisingly, an absence of risk reduction for dementia and cognitive loss was found and much reanalysis of these findings has focused on timing of hormone replacement. Here we take a broad perspective to address a fuller range of psychological health. Gender differences in other psychiatric conditions including depression and anxiety have been attributed to hormones, and the neurotransmitter systems that are implicated in affective disorders may have an impact on cognitive impairment as well. Hormonal influences on neurotrophic mechanisms, as well as neurotransmitter effects, may be responsible for a breadth of neuropsychiatric conditions, particularly in aging. This review will focus on cognition, mood and anxiety issues among women with an emphasis on changes associated with aging. We will review data on the epidemiology of these entities and examine the biological mechanisms, which may be involved, with an emphasis on those mechanisms that may contribute to the multiple aspects of neuropsychiatry and women's health.

5 Originating Grant

• 1.

  Sano, Mary

  Alzheimer's Disease Prevention Trial with Estrogens

  1 September 1998 - 31 July 2008

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 18,974,144

• 2.

  Salmon, David

  Alzheimer's Disease Cooperative Study (ADCS)

  1 July 1997 - 30 June 2012

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 5,782,372

• 3.

  SANO, MARY

  Alzheimer's Disease Research Center

  1 May 1997 - 31 March 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 16,937,375

• 4.

  Thal, Leon J

  ALZHEIMER'S DISEASE COOPERATIVE STUDY

  30 September 1991 - 31 August 2006

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 101,247,675

• 5.

  Davis, Kenneth L

  ALZHEIMERS DISEASE RESEARCH CENTER

  28 September 1984 - 31 March 2004

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 32,325,352

Scientific Context

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