The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Diabetes mellitus, hypertension and medial temporal lobe atrophy: the LADIS study.
E S C Korf; E C W van Straaten; F-E de Leeuw; W M van der Flier; F Barkhof; L Pantoni; A M Basile; D Inzitari; T Erkinjuntti; L-O Wahlund; et al. (Profiled Authors: Scheltens, Philip; Wahlund, Lars-Olof)
Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(2):166-71.
HYPOTHESIS: Based on recent findings on the association between vascular risk factors and hippocampal atrophy, we hypothesized that hypertension and diabetes mellitus (DM) are associated with medial temporal lobe atrophy (MTA) in subjects without disability, independent of the severity of white matter hyperintensities. METHODS: In the Leukoaraiosis And DISability in the elderly (LADIS) study, we investigated the relationships between DM, hypertension, blood pressure and MTA in 582 subjects, stratified by white matter hyperintensity severity, using multinomial logistic regression. MTA was visually scored for the left and right medial temporal lobe (score 0-4), and meaned. RESULTS: Mean age was 73.5 years (sd 5.1), 54% was female. Of the subjects, 15% had DM, and 70% had a history of hypertension. The likelihood of having MTA score 3 was significantly higher in subjects with DM (OR 2.9; 95% CI: 1.1-7.8) compared with an MTA score of 0 (no atrophy). The odds ratio for MTA score 2 was not significantly increased (OR 1.8; CI: 0.9-4). Systolic and diastolic blood pressure and a history of hypertension were not associated with MTA. There was no interaction between DM and hypertension. Stratification on white matter hyperintensities (WMH) did not alter the associations. CONCLUSION: Our study strengthens the observation that MTA is associated with DM, independently of the amount of small vessel disease as reflected by WMH.
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JAGUST, WILLIAM J.
15 September 2009 - 31 August 2014
NATIONAL INSTITUTE ON AGING
Total Funding: $ 1,954,514
B Miranda; S Madureira; A Verdelho; J Ferro; L Pantoni; E Salvadori; H Chabriat; T Erkinjuntti; F Fazekas; M Hennerici; et al.Journal of neurology, neurosurgery, and psychiatry 2008;79(8):869-73.
Salka S Staekenborg; Freek Gillissen; Rolinka Romkes; Yolande A L Pijnenburg; Frederik Barkhof; Philip Scheltens; Wiesje M van der FlierInternational journal of geriatric psychiatry 2008;23(4):387-92.
W M van der Flier; E C W van Straaten; F Barkhof; J M Ferro; L Pantoni; A M Basile; D Inzitari; T Erkinjuntti; L O Wahlund; E Rostrup; et al.Journal of neurology, neurosurgery, and psychiatry 2005;76(11):1497-500.
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