Younkin, Steven G

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Too much to count on: impaired very small numbers in corticobasal degeneration.

Casey Halpern; Robin Clark; Peachie Moore; Katy Cross; Murray Grossman (Profiled Author: Grossman, Murray)

Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA.
Brain and cognition 2007;64(2):144-9.

Patients with corticobasal degeneration (CBD) have calculation impairments. This study examined whether impaired number knowledge depends on verbal mediation. We focused particularly on knowledge of very small numbers, where there is a precise relationship between a cardinality and its number concept, but little hypothesized role for verbal mediation. We evaluated accuracy and reaction time (RT) for matching dot arrays and Arabic numerals involving smaller (2-4) and larger (5-9) cardinalities in non-aphasic patients with CBD (n=16), frontotemporal dementia (FTD; n=23), and healthy controls (n=15). CBD were less accurate and slowed at judging smaller Arabic numeral-dot array stimuli compared to FTD patients and controls. Moreover, only CBD showed longer RTs judging successively larger number-dot array pairs among the smaller cardinalities. Difficulty judging very small numbers is impaired in CBD, suggesting degraded representation of precise number knowledge that does not depend on language functioning.

4 Originating Grant

• 1.

  TROJANOWSKI, JOHN Q.

  Parkinson's Disease and Dementia

  15 June 2007 - 30 June 2017

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 11,949,028

• 2.

  GROSSMAN, MURRAY

  Neural Basis of Generalized Quantifiers

  1 May 2004 - 31 January 2015

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 5,533,675

• 3.

  LEE, VIRGINIA M

  Frontotemporal Dementias: Genotypes and Phenotypes

  15 March 2000 - 29 February 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 21,445,858

• 4.

  GROSSMAN, MURRAY

  Conceptual Processing in Alzheimer's Disease

  15 December 1997 - 31 July 2011

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,948,071

Scientific Context

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