The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Quantitative analysis of amyloid-beta peptides in cerebrospinal fluid using immunoprecipitation and MALDI-Tof mass spectrometry.
Valentina Gelfanova; Richard E Higgs; Robert A Dean; David M Holtzman; Martin R Farlow; Eric R Siemers; Amechand Boodhoo; Yue-Wei Qian; Xiaohua He; Zhaoyan Jin; et al. (Profiled Author: Farlow, Martin R)
Integrative Biology Division, Lilly Research Laboratories, Greenfield, IN 46140, USA.
Briefings in functional genomics & proteomics 2007;6(2):149-58.
Immunoprecipitation (IP) combined with matrix-assisted laser desorption ionization (MALDI) time of flight (Tof) mass spectrometry has been used to develop quantitative assays for amyloid-beta (Abeta) peptides in cerebrospinal fluid (CSF). Inclusion of (15)N labelled standard peptides allows for absolute quantification of multiple Abeta isoforms in individual samples. Characterization of variability associated with all steps of the assay indicated that the IP step is the single largest contributor to overall variability. Optimization of the assay resulted in overall coefficient of variation <or=8% with high agreement to an Abeta(1-40) and Abeta(1-42) ELISA assay. Application of the MALDI-Tof assay to CSF obtained from healthy volunteers and Alzheimer's disease patients indicated statistically significant 43% lower levels of Abeta(1-42) in the AD group (P = 0.0025).
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
GANDY, SAMUEL E
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NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE
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GOATE, ALISON M
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NATIONAL INSTITUTE ON AGING
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