Seubert, Peter

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration.

S X Xie; M S Forman; J Farmer; P Moore; Y Wang; X Wang; C M Clark; H B Coslett; A Chatterjee; S E Arnold; et al. (Profiled Authors: Lee, Virginia M-Y; Trojanowski, John Q; Grossman, Murray)

Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine Philadelphia, PA, USA.
Journal of neurology, neurosurgery, and psychiatry 2008;79(2):126-9.

OBJECTIVE: To examine the clinical and pathological factors associated with survival in autopsy-confirmed frontotemporal lobar degeneration (FTLD). METHODS: The final analysis cohort included 71 patients with pathologically proven FTLD, excluding patients with clinical motor neuron disease (MND), evaluated at the University of Pennsylvania or at the University of California, San Francisco. We assessed clinical and demographic features; cognitive functioning at presentation; genetic markers of disease; and graded anatomical distribution of tau, ubiquitin and amyloid pathology. RESULTS: The tau-negative group (n = 35) had a median survival time of 96 months (95% CI: 72-114 months), whereas the tau-positive group (n = 36) had a median survival time of 72 months (95% CI: 60-84 months). Patients with tau-positive pathology across all brain regions had shorter survival than those with tau-negative pathology in univariate Cox regression analyses (Hazard ratio of dying = 2.003, 95% CI = 1.209-3.318, p = 0.007). CONCLUSIONS: Tau-positive pathology represents a significant risk to survival in FTLD, whereas tau-negative pathology is associated with a longer survival time when clinical MND is excluded.

7 Originating Grant

• 1.

  MILLER, BRUCE L

  New Approaches to Dementia Heterogeneity

  15 May 2004 - 31 March 2014

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 14,656,380

• 2.

  GROSSMAN, MURRAY

  Neural Basis of Generalized Quantifiers

  1 May 2004 - 31 January 2015

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 5,533,675

• 3.

  MILLER, BRUCE L

  Frontotemporal Dementia: Genes, Images, and Emotions

  1 July 2001 - 31 August 2017

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 16,462,680

• 4.

  LEE, VIRGINIA M

  Frontotemporal Dementias: Genotypes and Phenotypes

  15 March 2000 - 29 February 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 21,445,858

• 5.

  GROSSMAN, MURRAY

  Conceptual Processing in Alzheimer's Disease

  15 December 1997 - 31 July 2011

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,948,071

• 6.

  TROJANOWSKI, JOHN Q.

  Alzheimer's Disease Core Center

  15 July 1997 - 30 June 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 25,158,594

• 7.

  Trojanowski, John Q

  Molecular substrates of aging and neuron death

  15 May 1997 - 30 April 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 24,601,856

Scientific Context

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