Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

A parametric comparison of diagnostic accuracy with three ordinal diagnostic groups.

Chengjie Xiong; Gerald van Belle; J Philip Miller; Yan Yan; Feng Gao; Kai Yu; John C Morris (Profiled Author: Morris, John C)

Division of Biostatistics, Washington University in St. Louis, St. Louis, MO 63110, USA. chengjie@wubios.wustl.edu
Biometrical journal. Biometrische Zeitschrift 2007;49(5):682-93.

Many medical diagnostic studies involve three ordinal diagnostic groups in which the diagnostic accuracy can be summarized by the volume or partial volume under a Receiver Operating Characteristic (ROC) surface. We study in this paper the statistical comparison of diagnostic accuracy from multiple diagnostic tests when three ordinal diagnostic groups are involved. Under the assumption that the multiple diagnostic tests follow a multivariate normal distribution within each diagnostic group, we provide the asymptotic variance and covariance for the maximum likelihood estimates of the volumes under the ROC surfaces from multiple diagnostic tests and propose statistical tests to test whether the diagnostic accuracy as measured by the volume under the ROC surface is the same for multiple diagnostic tests. We also propose a confidence interval estimate to the difference of two volumes under two ROC surfaces. Our approach depends crucially on the assumptions of normal distributions on diagnostic tests, which might not be robust when such assumptions are violated. Finally, we apply our proposed methodology to a real data set of 118 subjects to compare the diagnostic accuracy of early stage Alzheimer's disease (AD) from multiple neuropsychological tests.

2 Originating Grant

• 1.

  MORRIS, JOHN

  ALZHEIMERS DISEASE RESEARCH CENTER

  15 June 1997 - 30 April 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 29,005,627

• 2.

  MORRIS, JOHN

  HEALTHY AGING AND SENILE DEMENTIA

  1 January 1997 - 31 December 2013

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 30,196,104

Scientific Context

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