Seubert, Peter

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Molecular milestones that signal axonal maturation and the commitment of human spinal cord precursor cells to the neuronal or glial phenotype in development.

T Tohyama; V M Lee; L B Rorke; J Q Trojanowski (Profiled Authors: Lee, Virginia M-Y; Trojanowski, John Q)

Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.
The Journal of comparative neurology 1991;310(3):285-99.

Insights into the programmatic induction of neuronal and glial genes during human embryogenesis have depended largely on extrapolations of data derived from experimental mammals. However, the assumptions upon which these extrapolations are based have not been rigorously tested. Indeed, practically no information is available even on the human counterparts of the relatively small subset of well-characterized, developmentally regulated neuron and glial specific genes of the mammalian CNS. Thus, the developmental programs upon which human neural embryogenesis are based remain largely undeciphered. We have addressed this problem in immunohistochemical studies conducted on 22 human fetal spinal cords with gestational ages (GAs) that ranged from 6 to 40 weeks by using monoclonal antibodies to several classes of neuron or glial specific polypeptides. These polypeptides included: representatives of four different types (Types I-IV) of intermediate filament proteins, i.e., vimentin filament protein (VFP), glial fibrillary acidic protein (GFAP), different phospho-isoforms of the high (NF-H), middle (NF-M), and low (NF-L) molecular weight (Mr) neurofilament (NF) subunits, both acidic and basic cytokeratin (CK) proteins; three different microtubule associated proteins (MAPs), i.e., MAP2, MAP5, and tau; two different synaptic or coated vesicle proteins, i.e., synaptophysin (SYP) and clathrin light chain B (LCb); an oligodendroglial specific protein, i.e., myelin basic protein (MBP); and a receptor for a CNS trophic factor, i.e., the nerve growth factor receptor (NGFR).(ABSTRACT TRUNCATED AT 400 WORDS)

4 Originating Grant

• 1.

  Trojanowski, John Q

  Molecular substrates of aging and neuron death

  15 May 1997 - 30 April 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 24,601,856

• 2.

  TROJANOWSKI, JOHN Q

  CELL DEATH AND DIFFERENTIATION IN MEDULLOBLASTOMA

  1 December 1983 - 31 December 1999

  NATIONAL CANCER INSTITUTE

  Total Funding: $ 1,669,646

• 3.

  TROJANOWSKI, JOHN Q

  NEUROFILAMENT EXPRESSION AND TUMOR PROGRESSION

  1 December 1983 - 28 February 1995

  NATIONAL CANCER INSTITUTE

  Total Funding: $ 1,912,558

• 4.

  Lee, Virginia M

  REGULATION OF NEUROFILAMENT PHOSPHORYLATION & EXPRESSION

  Total Funding: $ 3,483,829

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.