Seubert, Peter

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications.

Daniel M Skovronsky; Virginia M-Y Lee; John Q Trojanowski (Profiled Authors: Lee, Virginia M-Y; Trojanowski, John Q)

Avid Radiopharmaceuticals, Inc., Philadelphia, Pennsylvania 19104, USA. skovronsky@avidrp.com
Annual review of pathology 2006;1():151-70.

Abstract Neurodegenerative diseases as diverse as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease share a common pathogenetic mechanism involving aggregation and deposition of misfolded proteins, which leads to progressive central nervous system disease. Although the type of aggregated protein and the regional and cellular distribution of deposition vary from disease to disease, these disorders may all be linked by similar pathways of protein aggregation with fibril formation and amyloid deposition. This perspective on pathogenesis suggests that a wide variety of neurodegenerative diseases can be grouped mechanistically as brain amyloidoses, an outlook that yields novel insights into potential therapeutic approaches that may be applicable across the broad spectrum of neurodegenerative disease.

4 Originating Grant

• 1.

  LEE, VIRGINIA M

  Frontotemporal Dementias: Genotypes and Phenotypes

  15 March 2000 - 29 February 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 21,445,858

• 2.

  TROJANOWSKI, JOHN Q.

  Alzheimer's Disease Core Center

  15 July 1997 - 30 June 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 25,158,594

• 3.

  Trojanowski, John Q

  Molecular substrates of aging and neuron death

  15 May 1997 - 30 April 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 24,601,856

• 4.

  Galasko, Douglas R

  Age related neurodegenerative diseases in Micronesia

  1 March 1997 - 31 March 2008

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 13,351,856

Scientific Context

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