Seubert, Peter

Publication Detail

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Physical activity and cognitive health.

M Kathryn Jedrziewski; Virginia M-Y Lee; John Q Trojanowski (Profiled Authors: Lee, Virginia M-Y; Trojanowski, John Q)

The Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. jedrzmk@mail.med.upenn.edu
Alzheimer's & dementia : the journal of the Alzheimer's Association 2007;3(2):98-108.

BACKGROUND: The industrialized nations are experiencing a demographic revolution due to the continuing increase in longevity and the rapid rise in the percentage of the population over 65 years old. Interventions that promote healthy aging will continue to gain significance as efforts to delay disability and loss of function intensify. METHODS: Since physical activity has been implicated in promoting healthy aging, here we review a large body of research that examines physical activity and cognitive health. Specifically, we focus on the associations of physical activity with cognitive function and dementia, including prevention, delay or slowing down of disease progression. Thus, we have prepared a descriptive review of the literature including various types of publications, prospective cohort, case-control, clinical trial and meta-analysis papers, published since 1999 in peer-reviewed journals. RESULTS: Based on currently available data, we conclude that the relative risk of cognitive decline with aging may diminish in individuals who are physically active; however, this has not been definitively demonstrated thus far. CONCLUSIONS: Further research is needed to determine conclusively the effects of physical activity on cognitive function and dementia and to elucidate the basis for this linkage.

4 Originating Grant

• 1.

  LEE, VIRGINIA M

  Frontotemporal Dementias: Genotypes and Phenotypes

  15 March 2000 - 29 February 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 21,445,858

• 2.

  TROJANOWSKI, JOHN Q.

  Alzheimer's Disease Core Center

  15 July 1997 - 30 June 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 25,158,594

• 3.

  Trojanowski, John Q

  Molecular substrates of aging and neuron death

  15 May 1997 - 30 April 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 24,601,856

• 4.

  Galasko, Douglas R

  Age related neurodegenerative diseases in Micronesia

  1 March 1997 - 31 March 2008

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 13,351,856

Scientific Context

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