Seubert, Peter

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments.

Kurt R Brunden; John Q Trojanowski; Virginia M-Y Lee (Profiled Authors: Lee, Virginia M-Y; Trojanowski, John Q)

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Journal of Alzheimer's disease : JAD 2008;14(4):393-9.

The discovery that mutations within the tau gene lead to frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) provided direct evidence that tau alterations can lead to neurodegenerative disease. While the presence of tau fibrils and tangles is a common feature of all tauopathies, including Alzheimer's disease (AD), data are emerging from biochemical, cell-based and transgenic mouse studies which suggest that a pre-fibrillar form of pathological tau may play a key role in eliciting central nervous system neurodegeneration and behavioral impairments. Herein we review recent findings that implicate diffusible tau pathology in the onset of neurodegeneration, and discuss the implications of these findings as they relate to tau tangles and possible therapeutic strategies for the treatment of AD and related tauopathies.

6 Originating Grant

• 1.

  MILLER, BRUCE L

  Frontotemporal Dementia: Genes, Images, and Emotions

  1 July 2001 - 31 August 2017

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 16,462,680

• 2.

  LEE, VIRGINIA M

  Frontotemporal Dementias: Genotypes and Phenotypes

  15 March 2000 - 29 February 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 19,741,888

• 3.

  Lee, Virginia M

  In Vitro in Vivo Models of Alzheimer's Disease

  1 September 1997 - 31 August 2008

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 16,839,357

• 4.

  MUFSON, ELLIOTT JAY

  Neurobiology of Mild Cognitive Impairment in the Elderly

  1 September 1997 - 31 March 2013

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 20,516,366

• 5.

  TROJANOWSKI, JOHN Q.

  Alzheimer's Disease Core Center

  15 July 1997 - 30 June 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 25,158,594

• 6.

  Trojanowski, John Q

  Molecular substrates of aging and neuron death

  15 May 1997 - 30 April 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 24,601,856

Scientific Context

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