Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Gene expression changes in the course of normal brain aging are sexually dimorphic.

Nicole C Berchtold; David H Cribbs; Paul D Coleman; Joseph Rogers; Elizabeth Head; Ronald Kim; Tom Beach; Carol Miller; Juan Troncoso; John Q Trojanowski; et al. (Profiled Authors: Cotman, Carl W; Trojanowski, John Q)

Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697-4540, USA.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15605-10.

Gene expression profiles were assessed in the hippocampus, entorhinal cortex, superior-frontal gyrus, and postcentral gyrus across the lifespan of 55 cognitively intact individuals aged 20-99 years. Perspectives on global gene changes that are associated with brain aging emerged, revealing two overarching concepts. First, different regions of the forebrain exhibited substantially different gene profile changes with age. For example, comparing equally powered groups, 5,029 probe sets were significantly altered with age in the superior-frontal gyrus, compared with 1,110 in the entorhinal cortex. Prominent change occurred in the sixth to seventh decades across cortical regions, suggesting that this period is a critical transition point in brain aging, particularly in males. Second, clear gender differences in brain aging were evident, suggesting that the brain undergoes sexually dimorphic changes in gene expression not only in development but also in later life. Globally across all brain regions, males showed more gene change than females. Further, Gene Ontology analysis revealed that different categories of genes were predominantly affected in males vs. females. Notably, the male brain was characterized by global decreased catabolic and anabolic capacity with aging, with down-regulated genes heavily enriched in energy production and protein synthesis/transport categories. Increased immune activation was a prominent feature of aging in both sexes, with proportionally greater activation in the female brain. These data open opportunities to explore age-dependent changes in gene expression that set the balance between neurodegeneration and compensatory mechanisms in the brain and suggest that this balance is set differently in males and females, an intriguing idea.

3 Originating Grant

• 1.

  Cotman, Carl W

  Brain Aging & Gene Expression Patterns Using Microarrays

  30 September 2003 - 31 July 2008

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 2,450,598

• 2.

  COTMAN, CARL WAYNE

  ADRC of the University of California, Irvine

  15 April 2000 - 31 March 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 19,671,992

• 3.

  COTMAN, CARL WAYNE

  Behavior and Neural Plasticity in the Aged

  1 August 1997 - 31 March 2013

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 30,822,252

Scientific Context

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