Hyman, Bradley T

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci.

Joseph H Lee; Rong Cheng; Neill Graff-Radford; Tatiana Foroud; Richard Mayeux; (Profiled Author: Mayeux, Richard)

Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Archives of neurology 2008;65(11):1518-26.

OBJECTIVE: To identify putative genetic loci related to the risk of late-onset Alzheimer disease (LOAD). DESIGN: Linkage analysis and family-based and case-control association analyses from a genomewide scan using approximately 6000 single-nucleotide polymorphic markers at an average intermarker distance of 0.65 cM. SETTING: The National Institute on Aging Genetics Initiative for Late-Onset Alzheimer's Disease (NIA-LOAD) was created to expand the resources for studies to identify additional genes contributing to the risk for LOAD. PARTICIPANTS: We investigated 1902 individuals from 328 families with LOAD and 236 unrelated control subjects. MAIN OUTCOME MEASURES: Clinical diagnosis of LOAD. RESULTS: The strongest overall finding was at chromosome 19q13.32, confirming the effect of the apolipoprotein E gene on LOAD risk in the family-based and case-control analyses. However, single-nucleotide polymorphisms at the following loci were also statistically significant in 1 or more of the analyses performed: 7p22.2, 7p21.3, and 16q21 in the linkage analyses; 17q21.31 and 22q11.21 in the family-based association analysis; and 7q31.1 and 22q12.3 in the case-control analysis. Positive associations at 7q31.1 and 20q13.33 were also significant in the meta-analysis results in a publicly available database. CONCLUSIONS: Several additional loci may harbor genetic variants associated with LOAD. This data set provides a wealth of phenotypic and genotypic information for use as a resource in discovery and confirmatory research.

7 Originating Grant

• 1.

  Mayeux, Richard

  Genetic Consortium for Late Onset Alzheimer's Disease

  30 September 2005 - 30 June 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 10,097,464

• 2.

  Mayeux, Richard P

  GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICS

  1 December 1998 - 31 January 2004

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 5,549,515

• 3.

  MAYEUX, RICHARD

  Genetic Epidemiology of Alzheimer's Disease in Hispanics

  1 December 1998 - 31 January 2014

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 10,703,458

• 4.

  TROJANOWSKI, JOHN Q.

  Alzheimer's Disease Core Center

  15 July 1997 - 30 June 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 25,158,594

• 5.

  SANO, MARY

  Alzheimer's Disease Research Center

  1 May 1997 - 31 March 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 16,937,375

• 6.

  Mayeux, Richard

  Epidemiology of Dementia In An Urban Community

  1 February 1989 - 30 June 2009

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 40,531,208

• 7.

  Davis, Kenneth L

  ALZHEIMERS DISEASE RESEARCH CENTER

  28 September 1984 - 31 March 2004

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 32,325,352

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.