The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Combined risk effects of IDE and NEP gene variants on Alzheimer disease.
S Vepsäläinen; S Helisalmi; A Mannermaa; T Pirttilä; H Soininen; M Hiltunen (Profiled Author: Soininen, Hilkka)
Department of Neurology, Kuopio University and University Hospital, PO Box 1627, 70211 Kuopio, Finland. email@example.com
Journal of neurology, neurosurgery, and psychiatry 2009;80(11):1268-70.
Polymorphisms in genes encoding amyloid beta-peptide (A beta)-degrading enzymes neprilysin (NEP) and insulin-degrading enzyme (IDE) individually affect the susceptibility to Alzheimer disease (AD) among the Finnish population. Here we show that a combination of risk genotypes for NEP and IDE genes leads to a higher susceptibility to AD. Individuals with the combination of risk genotypes for NEP and IDE conferred a threefold higher susceptibility to AD when compared with individuals not carrying these genotypes. Although no significant interaction was observed between NEP and IDE genes, these data suggest that NEP and IDE exhibit an additive risk effect in AD.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
TANZI, RUDOLPH EMILE
1 April 1999 - 30 April 2013
NATIONAL INSTITUTE OF MENTAL HEALTH
Total Funding: $ 6,796,019
Mayeux, Richard P
1 December 1998 - 31 January 2004
NATIONAL INSTITUTE ON AGING
Total Funding: $ 5,549,515
Smith, Mark A
1 May 1999 - 30 April 2006
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Total Funding: $ 750,386
Petra Nowotny; Anthony L Hinrichs; Scott Smemo; John S K Kauwe; Taylor Maxwell; Peter Holmans; Marian Hamshere; Dragana Turic; Luke Jehu; Paul Hollingworth; et al.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;136B(1):62-8.
Saila Vepsäläinen; Michele Parkinson; Seppo Helisalmi; Arto Mannermaa; Hilkka Soininen; Rudolph E Tanzi; Lars Bertram; Mikko HiltunenJournal of medical genetics 2007;44(9):606-8.
Behnosh F Björk; Hagit Katzov; Patrick Kehoe; Laura Fratiglioni; Bengt Winblad; Jonathan A Prince; Caroline GraffNeurobiology of aging 2007;28(9):1374-80.
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