Hyman, Bradley T

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Use of genetic variation as biomarkers for Alzheimer's disease.

Christiane Reitz; Richard Mayeux (Profiled Author: Mayeux, Richard)

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Annals of the New York Academy of Sciences 2009;1180():75-96.

Late-onset Alzheimer's disease (LOAD) is the most common cause of late-onset dementia in western societies. Despite remarkable achievements in human genetics throughout the years, in particular technological advances in gene mapping and in statistical methods that relate genetic variants to disease, to date only a small proportion of the genetic contribution to LOAD can be explained leaving several remaining genetic risk factors to be identified. A possible explanation for the difficulty in gene identification is that LOAD is a multifactorial complex disorder with both genetic and environmental components. Multiple genes with small effects each ("quantitative trait loci"[QTLs]) are likely to contribute to the quantitative traits associated with the disease, such as memory performance, amyloid/tau pathology, or hippocampal atrophy. The motivation for identifying the genetics of LOAD is clear. Not only could it shed light on disease pathogenesis, but it may also provide potential targets for effective treatment, screening, and prevention. Here, we review the usefulness of genetic variation as diagnostic tools and biomarkers in LOAD and discuss the potentials and difficulties researchers face in designing appropriate studies for gene discovery.

3 Originating Grant

• 1.

  MAYEUX, RICHARD

  Genetic Epidemiology of Alzheimer's Disease in Hispanics

  1 December 1998 - 31 January 2014

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 10,703,458

• 2.

  Mayeux, Richard P

  GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICS

  1 December 1998 - 31 January 2004

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 5,549,515

• 3.

  Mayeux, Richard

  Epidemiology of Dementia In An Urban Community

  1 February 1989 - 30 June 2009

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 40,531,208

Scientific Context

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