The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Variation within DNA repair pathway genes and risk of multiple sclerosis.
Farren B S Briggs; Benjamin A Goldstein; Jacob L McCauley; Rebecca L Zuvich; Philip L De Jager; John D Rioux; Adrian J Ivinson; Alastair Compston; David A Hafler; Stephen L Hauser; et al. (Profiled Authors: Haines, Jonathan L; Pericak-Vance, Margaret A.)
University of California, Berkeley, 94720, USA.
American journal of epidemiology 2010;172(2):217-24.
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system with a prominent genetic component. The primary genetic risk factor is the human leukocyte antigen (HLA)-DRB1*1501 allele; however, much of the remaining genetic contribution to MS has not been elucidated. The authors investigated the relation between variation in DNA repair pathway genes and risk of MS. Single-locus association testing, epistatic tests of interactions, logistic regression modeling, and nonparametric Random Forests analyses were performed by using genotypes from 1,343 MS cases and 1,379 healthy controls of European ancestry. A total of 485 single nucleotide polymorphisms within 72 genes related to DNA repair pathways were investigated, including base excision repair, nucleotide excision repair, and double-strand breaks repair. A single nucleotide polymorphism variant within the general transcription factor IIH, polypeptide 4 gene, GTF2H4, on chromosome 6p21.33 was significantly associated with MS (odds ratio = 0.7, P = 3.5 x 10(-5)) after accounting for multiple testing and was not due to linkage disequilibrium with HLA-DRB1*1501. Although other candidate genes examined here warrant further follow-up studies, collectively, these results derived from a well-powered study do not support a strong role for common variation within DNA repair pathway genes in MS.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Myers, Richard H
5 December 2001 - 31 January 2009
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Total Funding: $ 4,027,979
PERICAK-VANCE, MARGARET A.
1 April 2008 - 31 March 2013
NATIONAL INSTITUTE ON AGING
Total Funding: $ 5,843,348
HAINES, JONATHAN L.
1 April 2012 - 31 March 2015
NATIONAL EYE INSTITUTE
Total Funding: $ 397,302
M Ban; J L McCauley; R Zuvich; A Baker; L Bergamaschi; M Cox; A Kemppinen; S D'Alfonso; F R Guerini; J Lechner-Scott; et al.Genes and immunity 2010;11(8):660-4.
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Myriam Fornage; Stephanie Debette; Joshua C Bis; Helena Schmidt; M Arfan Ikram; Carole Dufouil; Sigurdur Sigurdsson; Thomas Lumley; Anita L DeStefano; Franz Fazekas; et al.Annals of neurology 2011;69(6):928-39.
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