Association of CLU and PICALM variants with Alzheimer's disease.

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

M Ilyas Kamboh; Ryan L Minster; F Yesim Demirci; Mary Ganguli; Steven T Dekosky; Oscar L Lopez; M Michael Barmada (Profiled Author: DeKosky, Steven T)

Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, United States. kamboh@pitt.edu
Neurobiology of aging 2012;33(3):518-21.

PubMed

Abstract

Two recent large genome-wide association studies have reported significant associations in the CLU (APOJ), CR1, and PICALM genes with the risk of Alzheimer's disease (AD). In order to replicate these findings, we examined 7 single nucleotide polymorphisms (SNPs) most significantly implicated by these studies in a large case-control sample comprising 2707 individuals. Principle components analysis revealed no population substructure in our sample. While no association was observed with CR1 SNPs (p = 0.30-0.457), a trend of association was seen with the PICALM (p = 0.071-0.086) and CLU (p = 0.148-0.258) SNPs. A meta-analysis of 3 studies revealed significant associations with all 3 genes. Our data from an independent and large case-control sample suggest that these gene regions should be followed up by comprehensive resequencing to find functional variants.

1 Originating Grant

1.

Dekosky, Steven T

Alzheimer's DIsease Research Center

1 May 1997 - 31 March 2010
NATIONAL INSTITUTE ON AGING
Total Funding: $ 23,347,917

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.

Related Grants

1.

TANZI, RUDOLPH EMILE

Identification of Functional Genomic Variants in Alzheimer's Disease

1 May 1999 - 30 April 2018
NATIONAL INSTITUTE OF MENTAL HEALTH
Total Funding: $ 3,474,948
2.

PERICAK-VANCE, MARGARET A.

Genomic Convergence in Alzheimer Disease

1 April 2008 - 31 March 2013
NATIONAL INSTITUTE ON AGING
Total Funding: $ 5,843,348
3.

Pericakvance, Margaret A

Alzheimer's Disease and Gene Discovery on Chromosome 9

30 September 2003 - 31 August 2008
NATIONAL INSTITUTE ON AGING
Total Funding: $ 583,588

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