The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation.
Michela Guglielmotto; Manuela Aragno; Elena Tamagno; Ilenia Vercellinatto; Sonia Visentin; Claudio Medana; Maria Graziella Catalano; Mark A Smith; George Perry; Oliviero Danni; et al. (Profiled Author: Perry, George)
Department of Experimental Medicine and Oncology, University of Turin, Turin, Italy.
Neurobiology of aging 2012;33(1):196.e13-27.
Although the pathogenesis of sporadic Alzheimer disease (AD) is not clearly understood, it is likely dependent on several age-related factors. Diabetes is a risk factor for AD, and multiple mechanisms connecting the 2 diseases have been proposed. Hyperglycemia enhances the formation of advanced glycation end products (AGEs) that result from the auto-oxidation of glucose and fructose. The interaction of AGEs with their receptor, named RAGE, elicits the formation of reactive oxygen species that are also believed to be an early event in AD pathology. To investigate a functional link between the disorders diabetes and AD, the effect of 2 AGEs, pentosidine and glyceraldehydes-derived pyridinium (GLAP), was studied on BACE1 expression both in vivo, in streptozotocin treated rats, and in vitro in differentiated neuroblastoma cells. We showed that pentosidine and GLAP were able to upregulate BACE1 expression through their binding with RAGE and the consequent activation of NF-κB. In addition, both pentosidine and GLAP were found to be increased in the brain in sporadic AD patients. Our findings demonstrate that activation of the AGEs/RAGE axis, by upregulating the key enzyme for amyloid-β production, provides a pathologic link between diabetes mellitus and AD.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Golde, Todd E
10 April 2000 - 30 April 2009
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Total Funding: $ 2,532,291
Gandy, Samuel E
1 September 2005 - 30 June 2008
NATIONAL INSTITUTE ON AGING
Total Funding: $ 898,167
Goate, Alison M
1 July 2005 - 30 June 2008
FOGARTY INTERNATIONAL CENTER
Total Funding: $ 117,923
Michela Guglielmotto; Manuela Aragno; Riccardo Autelli; Luca Giliberto; Erica Novo; Sebastiano Colombatto; Oliviero Danni; Maurizio Parola; Mark A Smith; George Perry; et al.Journal of neurochemistry 2009;108(4):1045-56.
Alessandra Piccini; Roberta Borghi; Michela Guglielmotto; Elena Tamagno; Gabriella Cirmena; Anna Garuti; Valeria Pollero; Sergio Cammarata; Michele Fornaro; Massimo Messa; et al.Journal of neurochemistry 2012;122(5):1023-31.
Kristina Leuner; Tanja Schütt; Christopher Kurz; Schamim H Eckert; Carola Schiller; Angelo Occhipinti; Sören Mai; Marina Jendrach; Gunter P Eckert; Shane E Kruse; et al.Antioxidants & redox signaling 2012;16(12):1421-33.
Appears in this Publication
Author of this Publication