University of Virginia

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Association of common KIBRA variants with episodic memory and AD risk.

Jeremy D Burgess; Otto Pedraza; Neill R Graff-Radford; Meron Hirpa; Fanggeng Zou; Richard Miles; Thuy Nguyen; Ma Li; John A Lucas; Robert J Ivnik; et al. (Profiled Authors: Dickson, Dennis; Younkin, Steven G; Petersen, Ronald C)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Neurobiology of aging 2011;32(3):557.e1-9.

KIBRA single nucleotide polymorphism (SNP) rs17070145 was identified in a genome-wide association study (GWAS) of memory performance, with some but not all follow-up studies confirming association of its T allele with enhanced memory. This allele was associated with reduced Alzheimer's disease (AD) risk in 1 study, which also found overexpression of KIBRA in memory-related brain regions of AD. We genotyped rs17070145 and 14 additional SNPs in 2571 late onset Alzheimer's disease (LOAD) patients vs. 2842 controls, including African-Americans. We found significantly reduced risk for rs17070145 T allele in the older African-American subjects (p = 0.007) and a suggestive effect in the older Caucasian series. Meta-analysis of this allele in > 8000 subjects from our and published series showed a suggestive protective effect (p = 0.07). Analysis of episodic memory in control subjects did not identify associations with rs17070145, though other SNPs showed significant associations in 1 series. KIBRA showed evidence of overexpression in the AD temporal cortex (p = 0.06) but not cerebellum. These results suggest a modest role for KIBRA as a cognition and AD risk gene, and also highlight the multifactorial complexity of its genetic associations.

5 Originating Grant

• 1.

  YOUNKIN, STEVEN G

  Plasma AB as a Surrogate Genetic Marker for LOAD

  1 April 2000 - 31 May 2013

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 3,283,760

• 2.

  Hutton, Michael L

  Tau and Neurodegeneration II: A therapeutic target

  1 September 1999 - 31 May 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 8,997,034

• 3.

  Dickson, Dennis William

  Tau and Neurodegeneration II: A therapeutic target

  1 September 1999 - 31 May 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,182,608

• 4.

  PETERSEN, RONALD C

  Mayo Alzheimer's Disease Research Center

  1 May 1999 - 30 April 2014

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 25,743,859

• 5.

  KATZMAN, ROBERT

  TEACHING NURSING HOME

  29 September 1982 - 31 August 1987

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 1,614,817

Scientific Context

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