Cotman, Carl W

Publication Detail

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Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders.

D Allan Butterfield; Eugenio Barone; Cesare Mancuso (Profiled Author: Butterfield, D Allan)

Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA. dabcns@uky.edu
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;64(3):180-6.

Statins, long known to be beneficial in conditions where dyslipidemia occurs by lowering serum cholesterol levels, also have been proposed for use in neurodegenerative conditions, including Alzheimer disease. However, it is not clear that the purported effectiveness of statins in neurodegenerative disorders is directly related to cholesterol-lowering effects of these agents; rather, the pleiotropic functions of statins likely play critical roles. Moreover, it is becoming more apparent with additional studies that statins can have deleterious effects in preclinical studies and lack effectiveness in various recent clinical trials. This perspective paper outlines pros and cons of the use of statins in neurodegenerative disorders, with particular emphasis on Alzheimer disease.

1 Originating Grant

• 1.

  Markesbery, William R

  Beta Amyloid and Oxidative Stress in Alzheimer's Disease

  15 May 1997 - 31 March 2013

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 17,393,197

Scientific Context

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