The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story.
Julio Acosta-Cabronero; Karalyn Patterson; Tim D Fryer; John R Hodges; George Pengas; Guy B Williams; Peter J Nestor (Profiled Author: Hodges, John R)
Herchel Smith Building for Brain and Mind Sciences, Cognition, Memory and Language Group, Neurology Unit, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Robinson Way, Cambridge CB20SZ, UK. firstname.lastname@example.org
Brain : a journal of neurology 2011;134(Pt 7):2025-35.
Semantic dementia, in which there is progressive deterioration of semantic knowledge, is associated with focal, typically asymmetric, temporal lobe degeneration. The ventrorostral temporal lobe is most severely affected and there is concordance between atrophy and reduced metabolic activity. In this study, we confirmed the veracity of this claim using ¹⁸F-fluorodeoxyglucose positron emission tomography and anatomical magnetic resonance images. The principal aim, however, was to understand the impact on neuronal projections from the ventrorostral temporal cortex lesion by studying the full extent of white matter changes, with no a priori assumptions about the nature or spatial location of the tracts involved. Using an unbiased voxel-wise approach known as tract-based spatial statistics, we compared results of whole-brain diffusion tensor imaging--absolute metrics of axial, radial and mean diffusion as well as fractional anisotropy--from 10 patients with mild/moderate semantic dementia and 21 matched controls. Distributions of increased absolute diffusivity and reduced fractional anisotropy for patients with semantic dementia were spatially concordant with each other. Abnormalities in all metrics were highly statistically significant in ventrorostral temporal white matter, more extreme on the left side, thus closely matching results from structural and functional imaging of grey matter. The most sensitive marker of change was radial diffusion. Local white matter tract abnormalities extended rostrally towards the frontal lobe and dorsocaudally towards the superior temporal and supramarginal gyri. To examine more remote changes, we performed a skeletonized probabilistic tractography analysis--'seeding' the rostral temporal voxels identified as abnormal in the patient group--in a healthy control group. Three major neural pathways were found to emanate from this 'seed region': uncinate, arcuate and inferior longitudinal fasciculi. At a less conservative threshold, tensor abnormalities in the semantic dementia group mapped onto the tractographies for the uncinate and arcuate bundles well beyond the rostral temporal lobe; this was not the case for the inferior longitudinal bundle, where abnormalities in semantic dementia did not extend caudal to the atrophic/hypometabolic zone. The results offer direct evidence for how the ventrorostral temporal lesion, proposed to be responsible for deteriorating semantic knowledge in semantic dementia and separate from 'classic' language areas, is associated with degeneration of efferent white matter projections to such language areas.
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LEE, VIRGINIA M
15 March 2000 - 29 February 2016
NATIONAL INSTITUTE ON AGING
Total Funding: $ 21,445,858
NATIONAL INSTITUTE ON AGING
Total Funding: $ 1,876,709
1 June 1976 - 31 May 1981
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Total Funding: $ 4,680,765
J L Whitwell; R Avula; M L Senjem; K Kantarci; S D Weigand; A Samikoglu; H A Edmonson; P Vemuri; D S Knopman; B F Boeve; et al.Neurology 2010;74(16):1279-87.
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