University of Göteborg

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Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease.

Michael Ewers; Susanne Schmitz; Oskar Hansson; Cathal Walsh; Annette Fitzpatrick; David Bennett; Lennart Minthon; John Q Trojanowski; Leslie M Shaw; Yetunde O Faluyi; et al. (Profiled Authors: Vellas, Bruno; Hampel, Harald; Blennow, Kaj; Trojanowski, John Q)

University of California, VA Medical Center, Center for Neuroimaging of Neurodegenerative Diseases , San Francisco, San Francisco, CA 94121, USA. michael.ewers@va.gov
Neurobiology of aging 2012;33(8):1599-608.

Weight changes are common in aging and Alzheimer's disease (AD) and postmortem findings suggest a relation between lower body mass index (BMI) and increased AD brain pathology. In the current multicenter study, we tested whether lower BMI is associated with higher core AD brain pathology as assessed by cerebrospinal fluid (CSF)-based biological markers of AD in 751 living subjects: 308 patients with AD, 296 subjects with amnestic mild cognitive impairment (MCI), and 147 elderly healthy controls (HC). Based upon a priori cutoff values on CSF concentration of total tau and beta-amyloid (Aβ(1-42)), subjects were binarized into a group with abnormal CSF biomarker signature (CSF+) and those without (CSF-). Results showed that BMI was significantly lower in the CSF+ when compared with the CSF- group (F = 27.7, df = 746, p < 0.001). There was no interaction between CSF signature and diagnosis or apolipoprotein E (ApoE) genotype. In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and nondemented elderly subjects.

1 Originating Grant

• 1.

  Jagust, William J

  UC Davis Alzheimer's Disease Center Core

  30 September 1991 - 30 June 2006

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 12,148,407

Scientific Context

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