The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Resting state fMRI in Alzheimer's disease: beyond the default mode network.
Federica Agosta; Michela Pievani; Cristina Geroldi; Massimiliano Copetti; Giovanni B Frisoni; Massimo Filippi (Profiled Author: Frisoni, Giovanni B)
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Neurobiology of aging 2012;33(8):1564-78.
Using resting state (RS) functional magnetic resonance imaging (fMRI), the connectivity patterns of the default mode (DMN), frontoparietal, executive, and salience networks were explored in 13 Alzheimer's disease (AD) patients, 12 amnestic mild cognitive impairment (aMCI) patients, and 13 healthy controls. Compared with controls and aMCI, AD was associated with opposing connectivity effects in the DMN (decreased) and frontal networks (enhanced). The only RS abnormality found in aMCI patients compared with controls was a precuneus connectivity reduction in the DMN. RS fMRI group differences were only partly related to gray matter atrophy. In AD patients, the mean executive network connectivity was positively associated with frontal-executive and language neuropsychological scores. These results suggest that AD is associated with an alteration of large-scale functional brain networks, which extends well beyond the DMN. In AD, the limited resources of the DMN may be paralleled, in an attempt to maintain cognitive efficiency, by an increased prefrontal connectivity. A medial parietal RS fMRI signal change seems to be present since the early phase of AD.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
JAGUST, WILLIAM J.
15 September 2009 - 31 August 2014
NATIONAL INSTITUTE ON AGING
Total Funding: $ 1,954,514
30 September 2003 - 30 June 2009
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Total Funding: $ 1,773,132
Cotman, Carl W
30 September 2003 - 31 July 2008
NATIONAL INSTITUTE ON AGING
Total Funding: $ 2,450,598
Audrey Duarte; Satoru Hayasaka; Antao Du; Norbert Schuff; Geon-Ho Jahng; Joel Kramer; Bruce Miller; Michael WeinerNeuroscience letters 2006;406(1-2):60-5.
Claudio Babiloni; Emanuele Cassetta; Giuliano Binetti; Mario Tombini; Claudio Del Percio; Florinda Ferreri; Raffaele Ferri; Giovanni Frisoni; Bartolo Lanuzza; Flavio Nobili; et al.The European journal of neuroscience 2007;25(12):3742-57.
Claudio Babiloni; Fabrizio Vecchio; Roberta Lizio; Raffaele Ferri; Guido Rodriguez; Nicola Marzano; Giovanni B Frisoni; Paolo M RossiniJournal of Alzheimer's disease : JAD 2011;26 Suppl 3():201-14.
Appears in this Publication
Author of this Publication