The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.
Giuseppe Astarita; Kwang-Mook Jung; Vitaly Vasilevko; Nicholas V Dipatrizio; Sarah K Martin; David H Cribbs; Elizabeth Head; Carl W Cotman; Daniele Piomelli (Profiled Author: Cotman, Carl W)
Department of Pharmacology, University of California Irvine, Irvine, California, United States of America.
PloS one 2011;6(10):e24777.
The molecular bases of Alzheimer's disease (AD) remain unclear. We used a lipidomic approach to identify lipid abnormalities in the brains of subjects with AD (N = 37) compared to age-matched controls (N = 17). The analyses revealed statistically detectable elevations in levels of non-esterified monounsaturated fatty acids (MUFAs) and mead acid (20:3n-9) in mid-frontal cortex, temporal cortex and hippocampus of AD patients. Further studies showed that brain mRNAs encoding for isoforms of the rate-limiting enzyme in MUFAs biosynthesis, stearoyl-CoA desaturase (SCD-1, SCD-5a and SCD-5b), were elevated in subjects with AD. The monounsaturated/saturated fatty acid ratio ('desaturation index')--displayed a strong negative correlation with measures of cognition: the Mini Mental State Examination test (r = -0.80; P = 0.0001) and the Boston Naming test (r = -0.57; P = 0.0071). Our results reveal a previously unrecognized role for the lipogenic enzyme SCD in AD.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
TANZI, RUDOLPH E
1 January 1994 - 31 December 1996
NATIONAL INSTITUTE ON AGING
Total Funding: $ 216,220
S Snigdha; G Astarita; D Piomelli; C W CotmanNeuroscience 2012;202():326-33.
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D Allan Butterfield; Eugenio Barone; Cesare MancusoPharmacological research : the official journal of the Italian Pharmacological Society 2011;64(3):180-6.
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