Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Human fetal tau protein isoform: possibilities for Alzheimer's disease treatment.

Nataša Jovanov-Milošević; Davor Petrović; Goran Sedmak; Mario Vukšić; Patrick R Hof; Goran Simić (Profiled Author: Hof, Patrick R)

Croatian Institute for Brain Research, University of Zagreb School of Medicine, Šalata 12, 10000 Zagreb, Croatia. njovanov@hiim.hr
The international journal of biochemistry & cell biology 2012;44(8):1290-4.

While early 1990s reports showed the phosphorylation pattern of fetal tau protein to be similar to that of tau in paired helical filaments (PHF) in Alzheimer's disease (AD), neither the molecular mechanisms of the transient developmental hyperphosphorylation of tau nor reactivation of the fetal plasticity due to re-expression of fetal protein kinases in the aging and AD human brain have been sufficiently investigated. Here, we summarize the current knowledge on fetal tau, adding new data on the specific patterns of tau protein and mRNA expression in the developing human brain as well as on change in tau phosphorylation in the perforant pathway after entorhinal cortex lesion in mice. As fetal tau isoform does not form PHF even in a highly phosphorylated state, understanding its expression and post-translational modifications represents an important avenue for future research towards the development of AD treatment and prevention.

2 Originating Grant

• 1.

  SANO, MARY

  Alzheimer's Disease Research Center

  1 May 1997 - 31 March 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 16,937,375

• 2.

  Davis, Kenneth L

  ALZHEIMERS DISEASE RESEARCH CENTER

  28 September 1984 - 31 March 2004

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 32,325,352

Scientific Context

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