Younkin, Steven G

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

The non-fluent/agrammatic variant of primary progressive aphasia.

Murray Grossman (Profiled Author: Grossman, Murray)

Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104-4283, USA. mgrossma@mail.med.upenn.edu
Lancet neurology 2012;11(6):545-55.

The non-fluent/agrammatic variant of primary progressive aphasia (naPPA) is a young-onset neurodegenerative disorder characterised by poor grammatical comprehension and expression and a disorder of speech sound production. In an era of disease-modifying treatments, the identification of naPPA might be an important step in establishing a specific cause of neurodegenerative disease. However, difficulties in defining the characteristic language deficits and heterogeneity in the anatomical distribution of disease in naPPA have led to controversy. Findings from imaging studies have linked an impairment of this uniquely human language capacity with disruption of large-scale neural networks centred in left inferior frontal and anterior superior temporal regions. Accordingly, the pathological burden of disease in naPPA is anatomically focused in these regions. Most cases of naPPA are associated with the spectrum of pathological changes found in frontotemporal lobar degeneration involving the microtubule-associated protein tau. Knowledge of these unique clinical-pathological associations should advance care for patients with this important class of neurodegenerative diseases while supplementing our knowledge of human cognitive neuroscience.

6 Originating Grant

• 1.

  LEE, VIRGINIA M

  TDP-43 Proteinopathies in ALS-Dementia

  30 September 2010 - 31 August 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 2,344,620

• 2.

  TROJANOWSKI, JOHN Q.

  Parkinson's Disease and Dementia

  15 June 2007 - 30 June 2017

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 11,949,028

• 3.

  GROSSMAN, MURRAY

  Neural Basis of Generalized Quantifiers

  1 May 2004 - 31 January 2015

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 5,533,675

• 4.

  LEE, VIRGINIA M

  Frontotemporal Dementias: Genotypes and Phenotypes

  15 March 2000 - 29 February 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 19,741,888

• 5.

  GROSSMAN, MURRAY

  Conceptual Processing in Alzheimer's Disease

  15 December 1997 - 31 July 2011

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,948,071

• 6.

  Grossman, Murray

  Cognitive Impairments in Parkinson's Disease and Aging

  1 July 1997 - 30 April 2007

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 3,064,177

Scientific Context

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