Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Immunoaffinity demonstration that paired helical filaments of Alzheimer disease share epitopes with neurofilaments, MAP2 and tau.

P Mulvihill; G Perry (Profiled Author: Perry, George)

Division of Neuropathology, Case Western Reserve University, Cleveland, OH 44106.
Brain research 1989;484(1-2):150-6.

Identification of the neuronal components incorporated into the neurofibrillary tangles of Alzheimer disease has primarily been derived from immunocytochemical procedures. Previous antibody studies have been able to directly determine the shared epitopes of known neuronal proteins with neurofibrillary tangles (NFT) only when the appropriate monoclonal antibodies were available. In this study, we use an immuno-affinity purification protocol to directly determine the properties of the epitopes recognized by two antisera which recognize NFT. Characterization of the purified antibodies demonstrates that NFT share epitopes with the two heavier neurofilament subunits. NFH and NFM, as well as MAP2 and tau. Further, this method indicates that the epitopes shared with neurofilaments and tau are distinct from each other.

2 Originating Grant

• 1.

  PERRY, GEORGE

  AMYLOID PRECURSOR IN ALZHEIMER DISEASE

  1 September 1988 - 31 August 1993

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 299,729

• 2.

  PERRY, GEORGE

  AMYLOID PRECURSOR IN ALZHEIMERS DISEASE

  1 April 1988 - 30 June 1995

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 536,600

Scientific Context

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