Miller, Bruce L

Publication Detail

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Comparison of rates of progression in Alzheimer's disease and Parkinson's disease.

T J Rosen; J H Growdon; S Corkin (Profiled Author: Growdon, John H)

Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge.
Journal of neural transmission. Supplementum 1987;24():105-7.

In order to compare the progression of memory impairments in Parkinson's disease (PD) and Alzheimer's disease (AD), we administered the Memory and Information section of the Blessed Dementia Scale (BDS) at least twice to 33 patients with PD and 70 with AD. The BDS scores of AD patients deteriorated over time. In contrast, the scores of PD patients were essentially stationary. A substantial difference in rate of cognitive decline persisted upon comparing only those PD and AD patients who showed memory deficits of the same magnitude. The uniform failure to observe cognitive deterioration among PD patients suggests that any PD patients who deteriorate at a rate typical of AD may indeed have AD or a related dementing disorder in addition to the characteristic nigral-striatal degeneration of PD.

2 Originating Grant

• 1.

  HYMAN, BRADLEY T

  Massachusetts Alzheimer's Disease Research Center

  1 April 1997 - 31 March 2014

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 13,238,070

• 2.

  Growdon, John H

  Massachusetts Alzheimer's Disease Research Center

  1 April 1997 - 31 March 2009

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 36,612,653

Scientific Context

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