Perry, Robert H

Publication Detail

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Effects of aging and cholinergic deafferentation on putative muscarinic cholinergic receptor subtypes in rat cerebral cortex.

A B Norman; S N Blaker; L Thal; I Creese (Profiled Author: Thal, Leon J)

Neuroscience letters 1986;70(2):289-94.

Despite a 34% decrease in the activity of choline acetyltransferase (ChAT) in the rat cerebral cortex following lesions of the nucleus basalis, there were no changes in the Bmax of the antagonist ligands [3H]quinuclidinyl benzilate ((-)-[3H]QNB) or (-)-[3H]N-methylscopolamine ((-)-[3H]NMS). Furthermore, this treatment produced no significant change in the proportions or affinities of muscarinic receptors having high and low affinity for pirenzepine or (-)-NMS. These data indicate that putative M2 muscarinic receptors are not restricted to ChAT-containing neurons in rat cerebral cortex. In senescent compared to mature rats there was no significant loss of ChAT activity although a significant reduction in the Bmax of both (-)-[3H]QNB and (-)-[3H]NMS binding was observed. However, no changes in the competition of pirenzepine or (-)-NMS for the remaining (-)-[3H]QNB binding sites were observed. Therefore, there is no evidence for any differential regulation of either putative muscarinic receptor subtype in response to cholinergic deafferentation or as a function of the natural aging process.

3 Originating Grant

• 1.

  Thal, Leon J

  Alzheimer's Disease Research Center

  1 April 1997 - 31 March 2009

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 33,330,208

• 2.

  GALASKO, DOUGLAS R

  Alzheimer's Disease Research Center

  1 April 1997 - 31 March 2014

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 17,184,030

• 3.

  KATZMAN, ROBERT

  ALZHEIMER'S DISEASE RESEARCH CENTER

  28 September 1984 - 31 March 1994

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 16,750,644

Scientific Context

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