The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation.
Department of Medicine (Neurology), Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC 27710, USA.
Neuroscience letters 1995;192(3):209-12.
The risk of Alzheimer's disease is determined, in part, by inheritance of specific alleles of ApoE. Isoform specific interactions of ApoE have been shown with the microtubule-associated protein tau, which forms the neurofibrillary tangle in this disease. Synthetic peptides representing each of the four microtubule-binding domains of tau more avidly bind ApoE3 than ApoE4. Phosphorylation of serine262 in domain I of tau decreases tau binding to microtubules and also abolishes binding by ApoE3. Understanding the molecular mechanisms of the high avidity, isoform-specific interactions of ApoE with tau may help in developing approaches for disease intervention.
1 Originating Grant
ROSES, ALLEN D
1 August 1988 - 31 July 1996
NATIONAL INSTITUTE ON AGING
Total Funding: $ 5,327,551
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
COLE, GREGORY M
1 September 2011 - 31 March 2016
NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE
Total Funding: $ 1,109,185
1 May 1985 - 30 September 2000
NATIONAL INSTITUTE ON AGING
Total Funding: $ 2,282,872
2 September 2011 - 30 June 2014
FOGARTY INTERNATIONAL CENTER
Total Funding: $ 70,352
W J Strittmatter; K H Weisgraber; M Goedert; A M Saunders; D Huang; E H Corder; L M Dong; R Jakes; M J Alberts; J R GilbertExperimental neurology 1994;125(2):163-71; discussion 172-4.
W J Strittmatter; A M Saunders; M Goedert; K H Weisgraber; L M Dong; R Jakes; D Y Huang; M Pericak-Vance; D Schmechel; A D RosesProceedings of the National Academy of Sciences of the United States of America 1994;91(23):11183-6.
A D Roses; G Einstein; J Gilbert; M Goedert; S H Han; D Huang; C Hulette; E Masliah; M A Pericak-Vance; A M Saunders; et al.Annals of the New York Academy of Sciences 1996;777():146-57.
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