Mufson, Elliott J

Publication Detail

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Increased number of NADPH-d-positive neurons within the substantia innominata in Alzheimer's disease.

W C Benzing; E J Mufson (Profiled Author: Mufson, Elliott J)

Department of Neurological Sciences, Alzheimer's Disease Center, Rush Presbyterian St Luke's Medical Center, Chicago, IL 60612, USA.
Brain research 1995;670(2):351-5.

NADPH-diaphorase histochemistry labels neurons containing nitric oxide synthase, the synthesizing for nitric oxide within the central nervous system. Quantitation revealed a statistically significant increase in the density of intensely (type 1) and moderately (type 2) but not lightly (type 3) NADPH-diaphorase stained neurons within the substantia innominata in AD as compared with age-matched controls. Increased numbers of NADPH-diaphorase neurons suggest excess nitric oxide production which may be neurotoxic to surrounding cholinergic neurons within the substantia innominata in Alzheimer's disease.

2 Originating Grant

• 1.

  MUFSON, ELLIOT J

  GALANIN PLASTICITY IN ALZHEIMERS DISEASE

  30 September 1992 - 31 July 1996

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 405,133

• 2.

  MUFSON, ELLIOTT JAY

  Galanin in Alzheimer's Disease

  29 September 1991 - 31 May 2012

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 5,750,823

Scientific Context

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