Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
The role of apolipoprotein E in the nervous system.
K H Weisgraber; A D Roses; W J Strittmatter (Profiled Authors: Roses, Allen D; Strittmatter, Warren J)
Gladstone Institute of Cardiovascular Disease, San Francisco, California.
Current opinion in lipidology 1994;5(2):110-6.
Human apolipoprotein (apo)E, an important component of plasma lipoprotein metabolism, was recently linked to Alzheimer's disease. Of the three common apoE alleles, epsilon 4 has emerged as a major risk factor. This review summarizes the data leading to this conclusion and discusses possible mechanisms for apoE involvement based on recent biochemical studies.
2 Originating Grant
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1.
Schmechel, Donald E
ALZHEIMER'S DISEASE RESEARCH CENTER
1 May 2000 - 30 April 2005
NATIONAL INSTITUTE ON AGING
Total Funding: $ 16,537,307
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2.
ROSES, ALLEN D
ALZHEIMERS DISEASE RESEARCH CENTER
30 September 1985 - 30 April 2000
NATIONAL INSTITUTE ON AGING
Total Funding: $ 17,660,528
Scientific Context
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Related Grants
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1.
COLE, GREGORY M
Preclinical Pharmacogenomics and Synaptic Biomarkers for Alzheimer's Disease
1 September 2011 - 31 March 2016
NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE
Total Funding: $ 1,109,185
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2.
Galasko, Douglas R
Biomarkers in Aging, MCI and Alzheimer's Disease
30 September 2003 - 31 July 2008
NATIONAL INSTITUTE ON AGING
Total Funding: $ 2,137,003
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3.
Knopman, David S
Frontotemporal degeneration: a basis for clinical trials
30 September 2003 - 31 August 2007
NATIONAL INSTITUTE ON AGING
Total Funding: $ 1,649,076
Related Publications
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1.
1994C R Harrington; J Louwagie; R Rossau; E Vanmechelen; R H Perry; E K Perry; J H Xuereb; M Roth; C M Wischik
The American journal of pathology 1994;145(6):1472-84. -
2.
1995W J Strittmatter; A D Roses
Apolipoprotein E and Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4725-7. -
3.
1995O Heinonen; M Lehtovirta; H Soininen; S Helisalmi; A Mannermaa; H Sorvari; O Kosunen; L Paljärvi; M Ryynänen; P J Riekkinen
Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele.
Neurobiology of aging 1995;16(4):505-13.
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