Iwatsubo, Takeshi

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Characterization of a novel processing pathway for Alzheimer's amyloid beta precursor protein.

J Ghiso; J E Gardella; L Liem; P D Gorevic; B Frangione (Profiled Author: Frangione, Blas)

Department of Pathology, New York University Medical Center, NY 10016.
Neuroscience letters 1994;171(1-2):213-6.

Amyloid beta (A beta) is a normal proteolytic fragment of a large precursor protein (beta PP) which undergoes altered conformation, leading to fibril formation. Two main beta PP processing pathways have been described, and we are now reporting the characterization of a third beta PP pathway. A membrane-associated 16 kDa component identified in human platelets isolated from normal donors. Based on size, immunoreactivity and amino acid sequence analysis, the fragment is a C-terminal beta PP component which starts at position 642 (APP770 numbering) and contains the intact A beta sequence. The presence of this novel pathway of beta PP processing in resting platelets suggest that it occurs as a normal event.

4 Originating Grant

• 1.

  Gandy, Samuel E

  Interdisciplinary Approach to Alzheimer Drug Discovery

  30 September 1991 - 31 August 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 11,063,275

• 2.

  GREENGARD, PAUL

  INTERDISCIPLINARY APPROACH TO ALZHEIMER DRUG DISCOVERY

  30 September 1991 - 31 July 1996

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 2,198,300

• 3.

  Frangione, Blas

  AMYLOID ANGIOPATHY, EARLY PLAQUES & AGING

  1 January 1990 - 31 August 2006

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,063,685

• 4.

  Frangione, Blas

  ALZHEIMERS DISEASE AND AMYLOID PROTEINS

  Total Funding: $ 4,881,560

Scientific Context

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