Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.

S Shimohama; G Perry; P Richey; T Takenawa; P J Whitehouse; K Miyoshi; T Suenaga; S Matsumoto; M Nishimura; J Kimura (Profiled Authors: Whitehouse, Peter J; Perry, George)

Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Neuroscience letters 1993;162(1-2):183-6.

We have previously demonstrated that an antibody to phosphoinositide-specific phospholipase C (PLC) isozyme, PLC-delta, intensely stained neurofibrillary tangles (NFT) in the brain tissue of Alzheimer's disease (AD). This study was performed to determine if abnormal PLC-delta accumulation might be present in the filamentous inclusions of other neurodegenerative diseases. We found that the anti-PLC-delta antibody stained neuronal inclusions of Pick's disease, progressive supranuclear palsy and diffuse Lewy body disease while the inclusions of idiopathic Parkinson's disease lacked PLC-delta accumulation. These results suggest a possible role for PLC-delta interaction in the formation of intraneuronal filamentous inclusions in human neurodegenerative diseases.

2 Originating Grant

• 1.

  PERRY, GEORGE

  NEUROFIBRILLARY PATHOLOGY IN ALZHEIMER DISEASE

  1 September 1990 - 30 November 2000

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 1,191,333

• 2.

  PERRY, GEORGE

  AMYLOID PRECURSOR IN ALZHEIMERS DISEASE

  1 April 1988 - 30 June 1995

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 536,600

Scientific Context

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