Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

The amyloid precursor protein in ischemic brain injury and chronic hypoperfusion.

R N Kalaria; S U Bhatti; W D Lust; G Perry (Profiled Author: Perry, George)

Department of Neurology, Case Western Reserve University, Cleveland, Ohio 44106.
Annals of the New York Academy of Sciences 1993;695():190-3.

We studied changes in the spatial and temporal distribution of the beta amyloid precursor protein (APP) of Alzheimer's disease (AD) in experimental ischemic brain injury. Rats with repeated reversible occlusions of one middle cerebral artery showed striking APP reactivity in astrocytic processes in perifocal regions and adjacent white matter. APP reactive dystrophic axons and neurons were also evident in the cortex and hippocampus ipsilateral to the MCA occlusion. Such changes were similarly apparent in animals subjected to partial forebrain ischemia induced by bilateral occlusion of the carotid arteries. Our studies suggest that focal ischemic insults or chronic hypoperfusion leads to increased accumulation or induction of APP in surviving cellular elements that may relate to the processes involved in beta amyloid deposition in AD.

2 Originating Grant

• 1.

  PERRY, GEORGE

  AMYLOID PRECURSOR IN ALZHEIMERS DISEASE

  1 April 1988 - 30 June 1995

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 536,600

• 2.

  WHITEHOUSE, PETER J

  UHC/CWRU ADRC COMPETITIVE RENEWAL

  Total Funding: $ 14,854,328

Scientific Context

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