Roses, Allen D

Publication Detail

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Molecular genetics of neurodegenerative diseases.

A D Roses (Profiled Author: Roses, Allen D)

Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Current opinion in neurology and neurosurgery 1993;6(1):34-9.

Recent progress in human neurogenetics has led to the discovery of new modes of inheritance and disease expression, including 1) stably inherited duplications in Charcot-Marie-Tooth disease type 1a, 2) dynamic mutations in fragile X syndrome and myotonic dystrophy, and 3) identical mutations with different phenotypes in fatal familial insomnia and Creutzfeldt-Jakob disease. The mechanisms by which known mutations of the amyloid precursor protein lead to early-onset Alzheimer's disease remain unexplained, despite hundreds of recent studies of beta-amyloid.

2 Originating Grant

• 1.

  ROSES, ALLEN D

  GENETICS OF LATE AND EARLY ONSET ALZHEIMERS DISEASE

  1 August 1988 - 31 July 1996

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 5,327,551

• 2.

  ROSES, ALLEN D

  HETEROZYGOTE DIAGNOSIS IN MYOTONIC MUSCULAR DYSTROPHY

  1 July 1983 - 31 March 1992

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 1,923,787

Scientific Context

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