Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Alpha 1-trypsin immunoreactivity in Alzheimer disease.

M A Smith; R N Kalaria; G Perry (Profiled Authors: Smith, Mark A; Perry, George)

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106-4901.
Biochemical and biophysical research communications 1993;193(2):579-84.

This study is the initial demonstration of trypsin-like immunoreactivity within the human CNS. Using two monoclonal antibodies to alpha 1-trypsin, we found trypsin-like immunoreactivity associated with the senile plaques of Alzheimer disease. Immunoblots prepared from homogenized Alzheimer and control cortex showed increased amounts of the 24,000Da alpha 1-trypsin species in diseased compared to control tissue. We suggest an alteration in alpha 1-trypsin protease regulation could be important in the formation of senile plaques and the pathogenesis of Alzheimer disease.

2 Originating Grant

• 1.

  PERRY, GEORGE

  NEUROFIBRILLARY PATHOLOGY IN ALZHEIMER DISEASE

  1 September 1990 - 30 November 2000

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 1,191,333

• 2.

  PERRY, GEORGE

  AMYLOID PRECURSOR IN ALZHEIMERS DISEASE

  1 April 1988 - 30 June 1995

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 536,600

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.