Pericak-Vance, Margaret A.

Publication Detail

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No association between very low density lipoprotein receptor (VLDL-R) and Alzheimer disease in American Caucasians.

M L Pritchard; A M Saunders; P C Gaskell; G W Small; P M Conneally; B Rosi; L H Yamaoka; A D Roses; J L Haines; M A Pericak-Vance (Profiled Authors: Haines, Jonathan L; Roses, Allen D; Saunders, Ann M; Small, Gary W; Pericak-Vance, Margaret A.)

Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Neuroscience letters 1996;209(2):105-8.

The very low density lipoprotein receptor gene (VLDL-R) is a receptor for apolipoprotein-epsilon (APOE)-containing lipoproteins, and thus has been suggested as a possible risk factor for Alzheimer disease (AD). Recently, Okuizumi et al. [Nature Genet, II (1995) 207-209] reported an association between the 96 bp allele at the VLDL-R locus and AD in a Japanese population. The association resulted in a two-fold increase of risk that decreased with increasing age. We have examined this association in 316 Caucasian sporadic AD patients, comparing their findings to 160 Caucasian AD spouse controls. We also investigated 53 late-onset Caucasian AD families for association and linkage. Our data failed to confirm linkage and/or association to the VLDL-R locus. Stratification by age at onset or APOE genotype also failed to show significant results.

3 Originating Grant

• 1.

  Schmechel, Donald E

  ALZHEIMER'S DISEASE RESEARCH CENTER

  1 May 2000 - 30 April 2005

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 16,537,307

• 2.

  Pericakvance, Margaret A

  Genetic Studies in Neurological Disorders

  1 March 1997 - 31 March 2009

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 18,660,474

• 3.

  ROSES, ALLEN D

  ALZHEIMERS DISEASE RESEARCH CENTER

  30 September 1985 - 30 April 2000

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 17,660,528

Scientific Context

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