Frangione, Blas

Publication Detail

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Alzheimer's soluble amyloid beta is a normal component of human urine.

J Ghiso; M Calero; E Matsubara; S Governale; J Chuba; R Beavis; T Wisniewski; B Frangione (Profiled Author: Frangione, Blas)

Department of Pathology, New York University Medical Center, New York 10016, USA.
FEBS letters 1997;408(1):105-8.

Soluble A beta (Sa beta) is normally present at a low concentration in human plasma and cerebrospinal fluid. Although the factors involved in the regulation of Sa beta plasma levels are still unknown, we have explored its excretion in the urine as one of the possible homeostatic mechanisms. The presence of Sa beta in the urine was investigated via immunoprecipitation experiments with anti-A beta antibodies followed by detection and identification by immunoblot, MALDI mass spectrometry and sequence analysis. Soluble A beta (4.3 kDa) immunoreactivity was present in the urine of normal donors, Down's syndrome individuals as well as in patients with renal disorders exhibiting glomerular or mixed proteinuria. Edman degradation of the immunoprecipitated material yielded the intact A beta N-terminus and mass spectra analysis indicated the existence of a major component at mlz 4327, corresponding to the molecular mass of A beta1-40. Semiquantitative data obtained from the immunoprecipitation experiments indicate that under normal conditions the daily excretion of intact Sa beta in the urine represents less than 1% of the circulating pool.

5 Originating Grant

• 1.

  Frangione, Blas

  Amyloidosis and Alzheimer's Disease

  1 July 1985 - 30 June 2007

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,467,436

• 2.

  FRANGIONE, BLAS

  AMYLOIDOSIS AND ALZHEIMERS DISEASE

  1 July 1985 - 30 June 1997

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 3,049,140

• 3.

  FRANGIONE, BLAS

  STRUCTURE OF IMMUNOGLOBULINS AND RELATED PROTEINS

  1 September 1978 - 31 March 1999

  NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

  Total Funding: $ 2,819,853

• 4.

  Frangione, Blas

  CONFORMATIONAL DISORDERS--AMYLOID AND PRION PROTEINS

  1 September 1978 - 31 March 2006

  NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

  Total Funding: $ 3,600,812

• 5.

  Frangione, Blas

  ALZHEIMERS DISEASE AND AMYLOID PROTEINS

  Total Funding: $ 4,881,560

Scientific Context

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