The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Abnormal localization of iron regulatory protein in Alzheimer's disease.
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. firstname.lastname@example.org
Brain research 1998;788(1-2):232-6.
A role for altered iron metabolism in the pathogenesis of Alzheimer's disease has been suggested by several reports associating the cardinal neuropathologic lesions with markers of free radical-induced damage and redox-active iron. We hypothesized that the abnormal distribution of iron in Alzheimer brain might result from alterations in iron regulatory proteins (IRP) such as IRP-1 and IRP-2, the main control elements of cellular iron homeostasis. Here, we report that while IRP-1 is present at similar levels in both Alzheimer and control brain tissue, IRP-2 shows striking differences and is associated with intraneuronal lesions, including neurofibrillary tangles, senile plaque neurites and neuropil threads. Since IRP-2 colocalizes with redox-active iron, our results suggest that alterations in IRP-2 might be directly linked to impaired iron homeostasis in Alzheimer's disease.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
ROGERS, JACK T
1 July 2012 - 30 June 2014
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Total Funding: $ 250,238
A M Thomson; J T Rogers; P J LeedmanThe Journal of biological chemistry 2000;275(41):31609-15.
H Gunshin; C R Allerson; M Polycarpou-Schwarz; A Rofts; J T Rogers; F Kishi; M W Hentze; T A Rouault; N C Andrews; M A HedigerFEBS letters 2001;509(2):309-16.
I Toth; L Yuan; J T Rogers; H Boyce; K R BridgesThe Journal of biological chemistry 1999;274(7):4467-73.
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